NTF3 activates NTRK2 (TRKB) signaling

Neurotrophin receptor tyrosine kinase NTRK2 (TRKB) is a low affinity receptor for neurotrophin-3 (NTF3, also known as NT-3) (Soppet et al. 1991). NTF3 predominantly functions as the ligand for the NTRK3 (TRKC) receptor (Marsh and Palfrey 1996). Binding to NTF3 can trigger NTRK2 dimerization (Ohira et al. 2001) and trans-autophosphorylation of NTRK2 dimers on conserved tyrosine residues in the cytoplasmic tail of the receptor (Middlemas et al. 1994). The efficacy of this process, however, is low in comparison to NTRK2 activation by BDNF and NTF3, and downstream signaling has not been studied.

神经生长因子受体酪氨酸激酶NTRK2（TRKB）是神经生长因子-3（NTF3，亦称NT-3）（Soppet等，1991年）的低亲和力受体。NTF3主要作为NTRK3（TRKC）受体的配体（Marsh和Palfrey，1996年）。与NTF3的结合可诱导NTRK2的二聚化（Ohira等，2001年）以及NTRK2二聚体在受体胞质尾保守酪氨酸残基上的跨自磷酸化（Middlemas等，1994年）。然而，相较于BDNF和NTF3激活NTRK2，此过程的效率较低，且下游信号传导尚未得到研究。