miRTARGET

miRTARGET is a powerful and user-friendly web tool for exploring miRNA targets with therapeutic or prognostic potential in cancer. It integrates experimental miRNA-related datasets and computational algorithms to generate prediction scores for targets of 1744 human miRNAs. The score is based on four dataset categories: mRNA profiling in cells or mice after (1) ectopic miRNA expression or (2) miRNA inactivation by knock-out or knock-down, (3) correlation analyses of mRNA and miRNA expression profiles, and (4) ten computational miRNA target prediction algorithms. In addition, miRTARGET integrates cancer-related datasets from primary tumors and cell lines, allowing users to filter/extract miRNA targets based on cancer cell line dependency, survival associations, and differential expression between tumor and normal tissues across 32 cancer entities.miRTARGET是一款功能强劲、操作便捷的网络工具，可用于探索癌症中具备治疗或预后应用潜力的微小RNA（miRNA）靶标。该工具整合了与miRNA相关的实验数据集与计算算法，可为1744种人类miRNA的靶标生成预测评分。该评分基于四大类数据集：① 经异位miRNA表达处理后的细胞或小鼠mRNA表达谱分析；② 通过敲除（knock-out）或敲低（knock-down）使miRNA失活后的细胞或小鼠mRNA表达谱分析；③ mRNA与miRNA表达谱的相关性分析；④ 十种计算型miRNA靶标预测算法。此外，miRTARGET整合了来自实体瘤与细胞系的癌症相关数据集，支持用户基于32种癌症实体的癌细胞系依赖性、生存相关性以及肿瘤与正常组织间的差异表达情况，对miRNA靶标进行筛选或提取。

搜集汇总

背景与挑战

背景概述

miRTARGET 是一个用户友好的综合性网络工具，用于识别和预测癌症中具有治疗或预后潜能的 microRNA 靶基因。它整合了实验数据、计算算法以及多种癌症相关数据集，为用户提供靶点预测评分并支持基于癌症特异性标准进行筛选和分析。