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Continuous analysis captures cellular states that reflect dominant effects of the HTT CAG repeat in human lymphoblastoid cell lines.

ChEBI2013-05-03 更新2026-07-21 收录

亨廷顿病发病机制

细胞模型表型分析

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-34721 数据链接链接失效反馈

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Continuous analysis captures cellular states that reflect dominant effects of the HTT CAG repeat in human lymphoblastoid cell lines.

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创建时间：

2013-05-03

亨廷顿病发病机制

神经退行性疾病

Objective To assess the prevalence, timing and functional impact of psychiatric, cognitive and motor abnormalities in Huntington’s disease (HD) gene carriers, we analysed retrospective clinical data

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data_sheet_1_Working Memory-Related Effective Connectivity in Huntington’s Disease Patients.docx

亨廷顿病发病机制

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Huntington’s disease (HD) is a genetically caused neurodegenerative disorder characterized by heterogeneous motor, psychiatric, and cognitive symptoms. Although motor symptoms may be the most prominen

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Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5

亨廷顿病发病机制

miRNA腺苷化调控

MicroRNAs (miRNAs) are small non-coding RNAs that play crucial roles in post-transcriptional gene regulation. Poly(A) RNA polymerase D5 (PAPD5) catalyzes the addition of adenosine to the 3' end of miR

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Table_11_Identification of Altered Developmental Pathways in Human Juvenile HD iPSC With 71Q and 109Q Using Transcriptome Profiling.XLSX

亨廷顿病发病机制

发育通路异常

In Huntington disease (HD) subtle symptoms in patients may occur years or even decades prior to diagnosis. HD changes at a molecular level may begin as early as in cells that are non-lineage committed

NIAID Data Ecosystem30

RNA-Seq analysis of unstimulated and LPS-stimulated monocytes from manifest HD and control subjects.

亨廷顿病发病机制

单细胞转录组学

Previous work has shown that HD myeloid cells are functionally abnormal, producing significantly more proinflammatory cytokines following LPS stimulation compared to control cells. While their phenoty

NIAID Data Ecosystem20

Continuous analysis captures cellular states that reflect dominant effects of the HTT CAG repeat in human lymphoblastoid cell lines.

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