Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity

Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity Descriptor: CHLORIDE ION, Insulin, PHENOL, ... Authors: Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A. Deposit date: 2010-10-04 Release date: 2011-11-23 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity To be Published

胰岛素纤维化是诱导契合（induced fit）的双面属性。手性钳（chiral clamp）以牺牲活性为代价稳定蛋白质天然构象。描述符：氯离子（CHLORIDE ION）、胰岛素（Insulin）、苯酚（PHENOL）等。作者：Q.X.华、Z.L.万、K.黄、S.Q.胡、N.F.菲利普、W.H.贾、J.惠廷厄姆、G.G.多德森、P.G.卡托扬尼斯、M.A.韦斯。提交日期：2010年10月4日；发布日期：2011年11月23日；最后修改日期：2024年11月20日。方法：X射线衍射（X-RAY DIFFRACTION，2.3 Å）。引用文献：胰岛素纤维化是诱导契合（induced fit）的双面属性。手性钳（chiral clamp）以牺牲活性为代价稳定天然构象。待发表。