Modulation of Amhr2 in mouse and human mesothelial cells

Amhr2 is as a specific biomarker for mesothelial cells. In this study, we investigated the impact of Amhr2 modulation on gene expression by overexpressing it in Met5a cells, a human mesothelial cell line. Additionally, we assessed the transcriptomic profile of tumor growth in Amhr2 knock-out mice. These experiments shed light on the role of Amhr2 in mesothelial cell function and its potential implications in tumor development Bulk RNA sequencing of Met5a cells, overexpressing two variants of the Amhr2 receptor: Amhr2-V3(V3), which is an inactive receptor, and Amhr2-V1(V1), which is an active receptor. Bulk RNA sequencing of mouse KPCA tumors derived from wild-type mice (CON) (C57BL6J), Amhr2 heterozygous (Het) and Amhr2 knock-out mice (KO). This dataset compare the genes expression profiles between these two groups.