2 acetyl-CoA <=> acetoacetyl-CoA + CoA

Acetyl-CoA acetyltransferase tetramer (ACAT1) in the mitochondrial matrix catalyzes the reversible reaction of two molecules of acetyl-CoA to form acetoacetyl-CoA and CoA (Middleton et al. 1986).

乙酰辅酶A乙酰转移酶四聚体（ACAT1）位于线粒体基质中，催化两个乙酰辅酶A分子可逆反应生成乙酰乙酰辅酶A和辅酶A（Middleton 等，1986年）。