Genome architectural screen reveals cell type–dependent modulators of DNA structure

To systematically identify biochemical determinants of whole-genome 3D architecture, we developed in-plate chromosome conformation capture (Plate-C) and profiled 2,956 samples spanning 834 conditions across five neuronal and glial cell types. We complemented these data with 6,081 single-cell chromatin conformation profiles generated using easy diploid chromosome conformation capture (Easy Dip-C) from HDAC inhibitor–treated newborn mouse brains, three bulk Dip-C datasets, 34 bulk RNA-seq datasets, and 200,893 single-cell transcriptomes.