Echocardiography and pathology of mice treated with and without dh404 for 4 wks after TAC.

Two dimension guided M-mode echocardiography and pathology were performed 4 weeks after the initiation of TAC or sham surgery in C57BL/6J mice treated with vehicle or dh404 as indicated.
Abbreviations: IVSd, interventricular septum diastolic; LVIDd, left ventricular internal dimension diastolic; LVIDs, left ventricular internal septum diastolic; LVPWd, left ventricular posterior wall diastolic; FS, fractional shortening; BW, body weight; HW/Tibia L, heart weight/tibia length ratio; LW/Tibia-L, lung weight/tibia length ratio.
ap<0.05 vs sham (0);
bp<0.05 vs TAC (0);
cp<0.05 vs TAC + dh404 (5 mg/kg/d);
dp<0.05 vs TAC + dh404 (10 mg/kg/d).