Loss-of-Function of the Hippo Transducer TAZ Reduces Mammary Tumor Growth through a Myeloid-Derived Suppressor Cell-Dependent Mechanism

TAZ, a key component in Hippo pathway, plays an important role in breast tumorigenesis. To understand the entrisic as well as extrinsic role of TAZ in mammary tumors, we performed RNA-seq analysis using mammary tumors generated from sgControl or sgTaz 4T1 cells. Overall design: sgContol or sgTaz induced mammary tumors were harvested, RNA were prepared and followed by RNA-seq analyzes.