Gene-gene interaction models.

This table shows 11 significant gene-gene interaction models discovered in the Marshfield PMRP cohort (M Pixn<0.01 and M Pmod<0.05, indicated by one to three stars). Six of these models show evidence for replication in the Vanderbilt BioVU cohort (M Pixn<0.05, M Pmod<0.1, indicated by two to three stars). In two of these replicating models, all three pairs of coefficients were in the same direction in both datasets (indicated by three stars). The table shows the two SNPs and their corresponding genes involved in the gene-gene interaction. All SNPs here were intronic SNPs. The coefficients for the main effects (β1 and β2) and the interaction term (β3) are shown for both the Marshfield cohort (prefixed by “M”), and the Vanderbilt cohort (prefixed by “V”). Also shown are the interaction term p-values (Pixn), ANOVA model fit p-values (Pmod), and overall R2 statistics for both the Marshfield and Vanderbilt cohorts (prefixed by “M” and “V” respectively).