Data from: Predictive value of apelin-12 in ST-elevation myocardial infarction patients with different renal function: a prospective observational study

Objectives: To investigate the factors predicting the onset of major
adverse cardiovascular events (MACEs) after primary percutaneous coronary
intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI)
patients. Background: apelin-12 has been regarded acting essential role in
cardiovascular homeostasis. However, current knowledge of the optimal
prognostic predictive value is limited. Methods: 464 STEMI patients
(63.0±11.9 years, 355 men) who underwent successful pPCI were enrolled.
Patients were followed-up for 2.5 years. Multivariate cox regression
analyses and receiver operating characteristic curve analysis were
performed to determine the factors predicting MACEs. Results: There were
118 patients (25.4%) who experienced MACEs in the follow-up period.
Multivariate cox regression analysis demonstrated that low apelin-12
(HR=0.132, 95% CI=0.060-0.292, p＜0.001), low left ventricular ejection
fraction (LVEF) (HR=0.965, 95% CI=0.941-0.991, p=0.007), low estimated
glomerular filtration rate (eGFR) (HR=0.985, 95% CI=0.977-0.993, p＜0.001),
Killip’s classification＞I (HR=0.610, 95% CI=0.408-0.912, p=0.016) and
pathological Q-wave (HR=1.536, 95% CI=1.058-2.230, p=0.024) were
independent predictors of 2.5 MACEs. Low apelin-12 could also predict
worse in-hospital prognosis and showed advantage in predicting 2.5 year
MACEs compared with Δapelin-12 (p=0.0115）and eGFR (p=0.0071) among
patients with eGFR＞90 mL/min1.73m2. Further analysis prompt Δapelin-12＜20%
was usually associated with MACEs in patients whose apelin-12 admission
below 0.76 ng/ml (p=0.0075). Conclusions: STEMI patients receiving pPCI
with lower apelin-12 are more likely to suffer MACEs in hospitalization
and 2.5-year follow-up, especially for those with normal level of eGFR.