The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with competitive inhibitor No. 9

The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with competitive inhibitor No. 9 Descriptor: 5-[2,3-bis(chloranyl)phenyl]furan-2-carboxylic acid, CALCIUM ION, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Levy, C.W, Leys, D. Deposit date: 2018-02-08 Release date: 2019-08-21 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. Commun Biol, 2, 2019

荧光假单胞菌（P.fluorescens）犬尿氨酸3-单加氧酶（Kynurenine 3-monooxygenase, KMO）与9号竞争性抑制剂结合的晶体结构。描述符：5-[2,3-二氯苯基]呋喃-2-羧酸、钙离子（CALCIUM ION）、黄素腺嘌呤二核苷酸（FLAVIN-ADENINE DINUCLEOTIDE）……作者：Levy C.W.、Leys D. 沉积日期：2018-02-08，发布日期：2019-08-21，最后修改日期：2024-05-01。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.65埃（Å）。引用文献：《可透过血脑屏障的神经退行性疾病靶点犬尿氨酸3-单加氧酶抑制剂可阻止神经毒性代谢产物蓄积》，发表于《通讯生物学（Communications Biology）》2019年，第2卷。