Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Urea Inhibitor
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Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Urea Inhibitor Descriptor: 3,4-dihydroquinolin-1(2H)-yl[4-(1H-imidazol-5-yl)piperidin-1-yl]methanone, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Loenze, P, Schimanski-Breves, S, Engel, C.K. Deposit date: 2011-02-16 Release date: 2012-02-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11beta-hydroxysteroid-dehydrogenase type 1. Bioorg.Med.Chem.Lett., 21, 2011
11β-羟类固醇脱氢酶1（11beta-Hydroxysteroid Dehydrogenase 1，11b-HSD1）与脲类抑制剂复合物的晶体结构，该抑制剂的化学标识为：3,4-二氢喹啉-1(2H)-基[4-(1H-咪唑-5-基)哌啶-1-基]甲酮；该靶点同时为类固醇11-β-脱氢酶同工酶1，复合物所含辅因子为还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH，DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）。作者：Loenze, P、Schimanski-Breves, S、Engel, C.K. 提交日期：2011-02-16 发布日期：2012-02-22 最后修改日期：2024-02-21 解析方法：X射线衍射（分辨率2.72埃） 引用文献：《吡咯烷-吡唑脲类强效选择性11β-羟类固醇脱氢酶1型抑制剂》，《生物有机与药物化学快报》，第21卷，2011年
创建时间：
2011-02-16
