Crystal Structure of the dioxygenase CcTet from Coprinopsis cinerea bound to 12bp 5-methylcytosine (5mC) containing duplex DNA
收藏资源简介:
Crystal Structure of the dioxygenase CcTet from Coprinopsis cinerea bound to 12bp 5-methylcytosine (5mC) containing duplex DNA Descriptor: 2OGFeDO JBP1/TET oxygenase domain-containing protein, DNA (5'-D(P*CP*GP*AP*TP*CP*(5CM)P*GP*CP*TP*AP*CP*G)-3'), DNA (5'-D(P*CP*GP*TP*AP*GP*CP*TP*GP*AP*TP*CP*G)-3'), ... Authors: Zhang, L, Zhang, L. Deposit date: 2023-06-01 Release date: 2024-03-06 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Molecular basis of an atypical dsDNA 5mC/6mA bifunctional dioxygenase CcTet from Coprinopsis cinerea in catalyzing dsDNA 5mC demethylation. Nucleic Acids Res., 52, 2024
灰盖鬼伞(Coprinopsis cinerea)来源的双加氧酶CcTet与含12bp 5-甲基胞嘧啶(5-methylcytosine, 5mC)的双链DNA结合的晶体结构 描述符:2OGFeDO 含JBP1/TET加氧酶结构域的蛋白质,DNA(5'-D(P*CP*GP*AP*TP*CP*(5CM)P*GP*CP*TP*AP*CP*G)-3'),DNA(5'-D(P*CP*GP*TP*AP*GP*CP*TP*GP*AP*TP*CP*G)-3')…… 作者:Zhang, L、Zhang, L. 提交日期:2023年6月1日 发布日期:2024年3月6日 最后修改日期:2024年5月8日 研究方法:X射线衍射(分辨率2.3埃) 引用文献:灰盖鬼伞中非典型双链DNA(double-stranded DNA, dsDNA)5mC/6mA双功能双加氧酶CcTet催化双链DNA 5mC去甲基化的分子基础。《核酸研究》(Nucleic Acids Res.), 52, 2024



