Erythropoietin activates STAT5

STAT5 (STAT5A or STAT5B) directly binds the phosphorylated cytoplasmic domain of EPOR, where it is phosphorylated by JAK2 and LYN (Oda et al. 1998, inferred from mouse homologs, reviewed in Kuhrt and Wojchowski 2015). Phosphorylated STAT5 then dissociates from EPOR, dimerizes, and transits to the nucleus where it activates gene expression.

STAT5（STAT5A或STAT5B）能够直接与磷酸化的EPOR细胞质结构域结合，该磷酸化过程由JAK2和LYN催化（Oda等，1998年研究，基于小鼠同源物推断，详见Kuhrt和Wojchowski，2015年综述）。磷酸化的STAT5随后与EPOR解离，形成二聚体，并迁移至细胞核中，从而激活基因表达。