The positions of ZFBS and ZFBS-Morph overlaps in the build bosTau8 of the Bos taurus genome

<p>In mammals, genomic imprinting results in the monoallelic expression of a subset of genes in a parent-of-origin specific manner.  This complex process is regulated by the Imprinting Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs).  In the mouse and the human genomes, the known ICRs/gDMRs include a set of composite DNA elements consisting of the ZFP57 binding site (ZFBS) overlapping a subset of the MLL1 morphemes.  It is thought that these composite elements (ZFBS-Morph overlaps) could be a key feature that drives the recruitment of the DNMT3A and DNMT3L complex for processive methylation of the ICRs in one of the parental alleles.  Furthermore, while ZFP57 selectively binds a CpG-methylated hexameric DNA sequence, MLL1 and MLL2 associate with a set of nonmethylation CpG-rich motifs known as the MLL1 morphemes.  Both MLL1 and MLL2 regulate transcription by modifying lysine 4 in histone H3 producing H3K4me3 marks in chromatin.   </p>

<p>This publication provides a text file that lists the positions of ZFBS and ZFBS-Morph overlaps in the build bosTau8 of the cow genome.  The file is in a format (.bed) suitable for upload at the UCSC genome browser to create a custom track.  To obtain and save a copy of the bed file, click on download at the top right corner of the page.  Alternatively, click <a href="http://genome.ucsc.edu/cgi-bin/hgTracks?org=cow&db=bosTau8&position=chr29:50,145,001-50,152,000&hgt.customText=https://purr.purdue.edu/publications/3359/serve?v=1" target="_blank"><em>here</em></a> to examine directly the listed positions at the UCSC genome browser. </p>

<p>If you observe anomalies on this page and if you encounter a problem with downloading the bed file, please contact bina@ purdue.edu.</p>