Post-transcriptional regulation of early-stage lymphopoiesis by Zc3h12a and Zc3h12c

The aim of this research is to dissect the post-transcriptional mechanisms of how gene expression is regulated in the early-stage lymphopoiesis. Zc3h12a is a critical regulator in controling Inflammation, which is mediated by mRNA decay mechanism via its nuclease activity. Zc3h12c is another family member of Zc3h12a that has an ability to destabilize mRNAs, although its biological role is unknown. We found that double-deficiency of Zc3h12a and Zc3h12c causes a profound loss of B cells in the periphery. However, a precise mechanism of lymphopoiesis by Zc3h12a and Zc3h12c remains to be clarified. The aim of this research project is to investigate the molecular mechanisms by which Zc3h12a and Zc3h12c regulate gene expressions to control lymphopoiesis.