Gene Expression of Bone Marrow Endothelial Cells under Radiated and Radioprotective Conditions

Bone Marrow Transplantation (BMT) depends greatly on transendothelial migration of stem cells from bloodstream to bone marrow. Therefore Bone Marrow Endothelial Cells (BMECs) becomes an essential component for successful BMT. Since BMT requires prior radiation therapy therefore it is necessary to study the behaviour of BMEC in irradiated and radiprotective conditions. We have conducted transcriptome profiling of Bone Marrow Endothelial Cells (BMECs) to identify the signalling mechanisms required for transendothelial migration to bone marrow under irradiated and radioprotected conditions. Gene Expression of Bone Marrow Endothelial Cells 24hrs after treatment of cells either with amifostine or 6Gy radiation or both amifostine and radiation.