Resistance to MEK1/2 inhibition through Slug upregulation

In this study, we analyzed the transcriptome of parental MIA PaCa-2 and acquired resistant cells to MEK1/2 inhibition. As a result, we observed that resistant cells exhibit an increased metastatic phenotype by using gene set enrichment analysis (GSEA) in the hallmark gene sets. We identified the transcription factor Slug in the RNASeq as the driver of resistance to MEK1/2 inhibition. Manuscript: The transcription factor Slug uncouples pancreatic cancer progression from the Raf-Mek1/2-Erk1/2 pathway.