NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors

NR1D1 (REV-ERBA) binds the promoter of the CLOCK gene and recruits corepressors to repress transcription. Recruitment of repressors appears to depend on the binding of heme by NR1D1.

NR1D1（REV-ERBA）结合CLOCK基因的启动子并募集核心抑制因子以抑制转录。抑制因子的募集似乎依赖于NR1D1与血红素的结合。