DataSheet_3_Effectiveness of transverse tibial bone transport in treatment of diabetic foot ulcer: A systematic review and meta-analysis.doc

BackgroundDiabetic foot ulcerations (DFUs) are a common but highly morbid complication of long-standing diabetes, carrying high rates of associated major amputation and mortality. Transverse tibial bone transport (TTT) has recently been applied for treatment of DFUs with the aim of accelerating wound healing. This study was performed to evaluate the effectiveness and safety of TTT in patients with DFUs.MethodsTwo authors independently retrieved the platforms of PubMed, Embase and CENTRAL, to identify studies associated with treatment of DFUs with TTT. Quantitative meta-analyses were performed to pool all available outcomes about the effectiveness and complications of TTT operation, with fixed- (I250%) model according to I2.ResultsA total of 7 studies, involving 818 participants, were included, with 661 participants treated with TTT operation. The pooled healing rate and limb salvage rate were 0.96 (95%CI: 0.93~0.98) and 0.98 (95%CI: 0.95~1.00) respectively after treatment with TTT. The pooled mean healing time was 15.03 (95%CI: 9.05~21.00) months. When compared with the pre-operative baseline values, the ankle-brachial index (ABI, MD: 0.23; 95%CI: 0.03~0.44; p

背景：糖尿病足溃疡（DFUs）是长期糖尿病的常见但严重并发症，伴随高比例的关联性大截肢和死亡率。横断胫骨骨转运术（TTT）近期被应用于治疗DFUs，旨在加速伤口愈合。本研究旨在评估TTT在DFUs患者中的有效性和安全性。方法：两位作者独立检索了PubMed、Embase和CENTRAL数据库，以识别与TTT治疗DFUs相关的研究。通过定量荟萃分析，对TTT手术的有效性和并发症的所有可用结果进行汇总，采用固定效应模型（I²=25%）。结果：共纳入7项研究，涉及818名参与者，其中661名参与者接受了TTT手术。接受TTT治疗后，汇总愈合率和肢体保存率分别为0.96（95%CI：0.93~0.98）和0.98（95%CI：0.95~1.00）。汇总平均愈合时间为15.03个月（95%CI：9.05~21.00个月）。与术前基线值相比，踝肱指数（ABI，MD：0.23；95%CI：0.03~0.44；p