Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoup

NIAID Data Ecosystem40

Phosphopeptides of p140Cap protein.

蛋白质磷酸化

癌症信号通路

Phosphopeptides of p140Cap protein.

NIAID Data Ecosystem20

A Systems Oncology Approach Identifies NT5E as a Key Metabolic Regulator in Tumor Cells and Modulator of Platinum Sensitivity

肿瘤代谢调控

药物敏感性

Altered metabolism in tumor cells is required for rapid proliferation but also can influence other phenotypes that affect clinical outcomes such as metastasis and sensitivity to chemotherapy. Here, a

NIAID Data Ecosystem50

Deleted in Liver Cancer 1 (DLC1) Negatively Regulates Rho/ROCK/MLC Pathway in Hepatocellular Carcinoma

癌症信号通路

细胞运动调控

AimsDeleted in liver cancer 1 (DLC1), a member of RhoGTPase activating protein (GAP) family, is known to have suppressive activities in tumorigenicity and cancer metastasis. However, the underlying mo

NIAID Data Ecosystem20

Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF

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