Predicted effects on protein stability for tubulin mutations.

All ΔΔG values predicted using FoldX using both the structure of the monomeric subunit (ddG_fold) and the full biological assembly (ddG_full). (CSV)

NIAID Data Ecosystem30

Predictions of protein stability change due to mutations.

For all the predictions, pH and temperature were selected as 7.0 and 25°C, respectively. WT: Wild type amino acid, MT Mutant type amino acid, ΔΔG: ΔG(New Protein)-ΔG(Wild Type) in Kcal/mol (ΔΔG0: Incr

Figshare2015-12-02 更新00

The most poorly predicted pathogenic tubulin mutations.

For each of the VEPs used in this study, cumulative distribution ranks were generated in a combined dataset of putatively benign and pathogenic tubulin variants. MCD scores for each variant were calcu

Figshare2022-10-07 更新00