The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinic acid

The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinic acid Descriptor: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... Authors: Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. Deposit date: 2022-06-17 Release date: 2022-12-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023

本数据集为甲型H1N1流感病毒聚合酶PA核酸内切酶的N端结构域与4-(苄氧基)-6-溴-3-羟基吡啶甲酸（4-(benzyloxy)-6-bromo-3-hydroxypicolinic acid）形成的复合物。配体描述：6-溴-3-羟基-4-氧代-1,4-二氢吡啶-2-羧酸、乙酸根离子（ACETATE ION）、锰(II)离子（MANGANESE (II) ION）等。作者：Kohlbrand, A.J.、Stokes, R.W.、Karges, J.、Seo, H.、Sankaran, B.、Cohen, S.M.。提交日期：2022-06-17，发布日期：2022-12-21，最后修改日期：2023-10-25。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.15埃（Å）。引用文献：《作为流感核酸内切酶抑制剂核心骨架的羟基吡啶酮羧酸生物等排体衍生物》，发表于《Acs Med.Chem.Lett.》2023年第14卷。