Extracellular matrix proteins novel in the zebrafish skeleton.

Of the 123 extracellular proteins that were differentially abundant during zebrafish skeletal development, a subset of 40 proteins was identified as novel proteins in zebrafish skeletal development based on whether they were previously characterized or identified in skeletal tissues of other vertebrate species (mouse, rat, human). In addittion, 6 were considered as novel in vertebrate skeletogenesis in general (bottom). a Indicates proteins previously studied based on their gene expression pattern by in situ hybridization in stages up to 5 dpf. Proteins that were not selected for relative quantification based on described criteria (Materials and Methods section) are marked (N.S.). * Significantly differential abundant proteins based on their significance at a threshold of FDR = 0.05. ** Significantly differential abundant proteins based on their significance at a threshold of FDR = 0.01.