Effect of adipose tissue insulin resistance on gene expression of liver in diet-induced NASH model.

To investigate the alterlation of liver gene expression in diet-induced NASH model with adipose tissue insulin resistance, we evaluated liver of control mice and adipocyte-specific PDK1 knockout (PDK1KO) mice fed either normal chow(NC) or Gubra amylin NASH (GAN) diet for 16weeks after weaning at 4 weeks old. We then performed gene expression profiling analysis using data obtained from RNA-seq of these 4 groups. Comparative gene expression profiling analysis of RNA-seq data for liver of 4 groups[Control(NC), Contro(GAN), PDK1KO(NC),PDK1KO(GAN)].