E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-methylpyrimidine-5-carboxamido)-N-methylbutanamido)-16,26-bis(2-aminoethoxy)-N-(2-iminoethyl)-7-methyl-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacyclodecaphane-4-carboxamide)

E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-methylpyrimidine-5-carboxamido)-N-methylbutanamido)-16,26-bis(2-aminoethoxy)-N-(2-iminoethyl)-7-methyl-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacyclodecaphane-4-carboxamide) Descriptor: (8S,11S,14S)-14-{[(2S)-4-amino-2-{[2-(4-tert-butylphenyl)-4-methylpyrimidine-5-carbonyl]amino}butanoyl](methyl)amino}-3,18-bis(2-aminoethoxy)-N-[(2Z)-2-iminoethyl]-11-methyl-10,13-dioxo-9,12-diazatricyclo[13.3.1.1~2,6~]icosa-1(19),2(20),3,5,15,17-hexaene-8-carboxamide, PENTAETHYLENE GLYCOL, Signal peptidase I Authors: Murray, J.M, Rouge, L. Deposit date: 2017-10-05 Release date: 2018-10-10 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.407 Å) Cite: Optimized arylomycins are a new class of Gram-negative antibiotics. Nature, 561, 2018

大肠杆菌（E. coli）LepB与GNE0775的复合物（(4S,7S,10S)-10-((S)-4-氨基-2-(2-(4-(叔丁基)苯基)-4-甲基嘧啶-5-甲酰胺基)-N-甲基丁酰胺基)-16,26-双(2-氨基乙氧基)-N-(2-亚氨基乙基)-7-甲基-6,9-二氧代-5,8-二氮杂-1,2(1,3)-二苯环癸烷-4-甲酰胺）。描述符：(8S,11S,14S)-14-{[(2S)-4-氨基-2-{[2-(4-叔丁基苯基)-4-甲基嘧啶-5-羰基]氨基}丁酰基](甲基)氨基}-3,18-双(2-氨基乙氧基)-N-[(2Z)-2-亚氨基乙基]-11-甲基-10,13-二氧代-9,12-二氮杂三环[13.3.1.1~2,6~]二十碳-1(19),2(20),3,5,15,17-六烯-8-甲酰胺、五乙二醇（PENTAETHYLENE GLYCOL）、信号肽酶I（Signal peptidase I）。作者：Murray, J.M.、Rouge, L.。沉积日期：2017-10-05。发布日期：2018-10-10。最后修改日期：2024-11-06。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.407埃（Å）。引用文献：《优化的芳基霉素类为一类新型革兰氏阴性抗生素》，《自然》（*Nature*），第561卷，2018年