Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

The loss of Tmem106b results in an age-dependent loss of cerebellar Purkinje cells accompanied with motor function deficits. Tmem106b deficiency also results in lysosomal enlargement in both Purkinje cells and microglia, and increased neuroinflammation including complement system activation. These data suggest that, in addition to myelination, Tmem106b also plays important role in maintaining the health and survival of cerebellar Purkinje cells during aging. we performed transcriptomic analyses of RNA from cerebellar tissues harvested from 15-month-old Tmem106b mice [3 Tmem106b+/+ (WT), and 3 Tmem106b-/- (KO), 2 males and 1 females per genotype].