Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with compound AZ13644908

Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with compound AZ13644908 Descriptor: (2R)-2-({4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}amino)-2-phenylethyl (2-aminoethyl)carbamate, SULFATE ION, UDP-N-acetylmuramate--L-alanine ligase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2022-09-12 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa to be published铜绿假单胞菌（Pseudomonas aeruginosa）UDP-N-乙酰胞壁酰-L-丙氨酸连接酶（UDP-N-acetylmuramate-L-alanine ligase，又称UDP-N-乙酰胞壁酰-L-丙氨酸合成酶，MurC）与化合物AZ13644908结合的晶体结构 配体与复合物组分描述：(2R)-2-({4-[(5-叔丁基-1-甲基-1H-吡唑-3-基)氨基]-1H-吡唑并[3,4-d]嘧啶-6-基}氨基)-2-苯乙基(2-氨基乙基)氨基甲酸酯、硫酸根离子、UDP-N-乙酰胞壁酰-L-丙氨酸连接酶 作者：西雅图传染病结构基因组学中心（Seattle Structural Genomics Center for Infectious Disease, SSGCID） 提交日期：2022-09-12 发布日期：2022-10-05 最后修改日期：2023-10-18 实验方法：X射线衍射（2.2 Å） 引用信息：铜绿假单胞菌UDP-N-乙酰胞壁酰-L-丙氨酸连接酶（UDP-N-acetylmuramate-L-alanine ligase，UDP-N-乙酰胞壁酰-L-丙氨酸合成酶，MurC）的晶体结构，待发表