We report that TRAF4-mediated AR ubiquitination alters AR genomic binding profile under androgen deprivation condition. Overall design: Examination of AR genome-wide binding in control and TRAF4 overe

NIAID Data Ecosystem50

Molecular data integration reveals Growth Hormone Receptor as an alternative candidate oncogenic signaling pathway in glioblastoma

胶质母细胞瘤分子机制

生长激素受体信号通路

Our laboratory has identified the Growth Hormone Receptor (GHR) as a candidate oncogenic pathway involved in GBM oncogenicity. In order to study further the role of GHR in GBM, we have generated GHR

NIAID Data Ecosystem30

Global Mapping at the Core of the Arabidopsis Circadian Clock Defines the Network Structure of the Oscillator

生物钟调控

全基因组结合位点分析

In many organisms, the circadian clock is composed of functionally coupled morning and evening oscillators that regulate the bouts of dawn and dusk activity. In Arabidopsis, oscillator coupling relies

NIAID Data Ecosystem60

A whole genome-screening strategy to identify DNA2 binding sites and genomic regions that require DNA2 for replication

锥虫kDNA复制机制

全基因组结合位点分析

We report that DNA2 predominantly bound to the centromeric α-satellite regions. The centromeric regions contained 58% of the DNA2-associated DNA, representing a 33.5-fold enrichment over genomic input

NIAID Data Ecosystem40

Genome-wide analysis of insulin-like growth factor 1 receptor (IGF1R) binding sites in DFB cells

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