Gene expression analysis in mouse mature T-cells either upon knockdown of L3MBTL3 or rescue with RBPJ WT or F261A/A284V mutant

We identified genes upregulated upon depletion of L3MBTL3 in mouse mature T-cells (MT). Additionally, we identified genes downregulated upon rescue with RBPJ WT but not with an L3MBTL3-interacting defecting mutant (F261A/A284V) in MT cells depleted of RBPJ using the CRISPR/Cas9 technology. Overall design: RNA-seq analysis of mouse mature T-cells either upon knockdown of L3MBTL3 or rescue with RBPJ WT or F261A/A284V mutant.