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Essential functions for ID proteins at multiple checkpoints in natural killer T cell development

ChEBI2013-11-19 更新2026-07-21 收录

iNKT细胞发育

ID蛋白功能

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-50933 数据链接链接失效反馈

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资源简介：

Essential functions for ID proteins at multiple checkpoints in natural killer T cell development

应用场景：

创建时间：

2013-11-19

转录因子调控

iNKT细胞发育

To identify genes that require PLZF for their regulation in NKT cells, we compared the developmental stages of thymic NKT cells from wildtype and PLZF-deficient mice The transcription factor PLZF is i

NIAID Data Ecosystem60

Multiple levels of transcriptional regulation by PLZF in NKT cell development [MoEx-1_0-st]. Mus musculus

iNKT细胞发育

转录调控机制

To identify genes that PLZF is sufficient to modulate in T cells, we compared CD4+ CD8- (CD4SP) thymocytes that overexpressed PLZF to their wildtype counterparts The transcription factor PLZF is induc

NIAID Data Ecosystem30

RNA sequencing of WT and Uhrf1 KO iNKT cells

iNKT细胞发育

AKT/mTOR信号通路

Deletion of Uhrf1 resulted in stage 1-specific defects during iNKT cell development. To investigate the molecular mechanism, we sorted WT and Uhrf1-KO stage 1 iNKT cells and performed RNA-seq. By comp

Alliance of Genome Resources20

Critical role for very-long chain sphingolipids in invariant natural killer T cell development and homeostasis

免疫代谢

iNKT细胞发育

The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety

NIAID Data Ecosystem30

TET proteins regulate lineage specification and TCR-mediated expansion of iNKT cells (CMS-Seq)

iNKT细胞发育

表观遗传调控

TET proteins oxidize 5-methylcytosine to 5-hydroxymethylcytosine and further oxidation products in DNA. Here we report that simultaneous deletion of Tet2 and Tet3 in mouse double-positive thymocytes r

NIAID Data Ecosystem20

Essential functions for ID proteins at multiple checkpoints in natural killer T cell development

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