NMR structure of a synthetic small molecule, rbt203, bound to HIV-1 TAR RNA

Protein Data Bank Japan2024-05-15 更新2026-03-21 收录

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NMR structure of a synthetic small molecule, rbt203, bound to HIV-1 TAR RNA Descriptor: N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE, RNA (5'-(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP *CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C) -3') Authors: Davis, B, Afshar, M, Varani, G, Karn, J, Murchie, A.I.H, Lentzen, G, Drysdale, M.J, Potter, A.J, Bower, J, Aboul-Ela, F. Deposit date: 2003-12-18 Release date: 2004-03-15 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots" J.Mol.Biol., 336, 2004

与HIV-1反式激活响应RNA（HIV-1 TAR RNA）结合的合成小分子rbt203的核磁共振（Nuclear Magnetic Resonance, NMR）结构描述符：N-[2-(2-{[(4-{[氨基(亚氨基)甲基]氨基}丁基)氨基]甲基}-4-甲氧基苯氧基)乙基]胍，RNA（5'-(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP *CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C) -3'）作者：Davis, B、Afshar, M、Varani, G、Karn, J、Murchie, A.I.H、Lentzen, G、Drysdale, M.J、Potter, A.J、Bower, J、Aboul-Ela, F. 提交日期：2003-12-18 发布日期：2004-03-15 最后修改日期：2024-05-15 实验方法：溶液态核磁共振（NMR）引用：《通过稳定静电"热点"理性设计HIV-1 TAR RNA抑制剂》，J.Mol.Biol., 336, 2004

创建时间：

2003-12-18