A compendium of promoter-centered long-range chromatin interactions in diverse human tissues and cell types

A large number of genetic variants associated with human diseases are found in non-coding DNA and may contribute to illness by affecting gene regulation, but mechanistic study of these variants has been hindered by a lack of information of their potential regulatory targets. In order to overcome this limitation, we generate maps of long-range chromatin interactions centered on 19,539 promoters in 27 human cell/tissue types, and use this information to infer putative target genes of candidate cis-regulatory sequences throughout the human genome. In additional to known enhancer-promoter interactions, we also confirm widespread promoter-promoter interactions and obtain evidence suggesting enhancer-like function for many promoter regions. These promoter-centered chromatin interaction maps corroborate target genes of genetic variants defined in previous genome-wide association studies, predict new target genes of many disease-associated genetic variants, and contribute novel insights into a broad spectrum of human traits and diseases. Overall design: The study contains promoter capture Hi-C results for diverse human cell/tissue types .bz2, text files for promoter capture Hi-C chromatin interaction between DNA fragments for promoter-promoter interactions (PP) or promoter-other interactions (PO) pp: P-P interaction frequency po: P-O interaction frequency