Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster

Experimental evolution studies that feature selection on life-history characters are a proven approach for studying the evolution of aging and variation in rates of senescence. Recently, the incorporation of genomic and transcriptomic approaches into this framework has led to the identification of hundreds of genes associated with different aging patterns. However, our understanding of the specific molecular mechanisms underlying these aging patterns remains limited. Here, we incorporated extensive metabolomic profiling into this framework to generate mechanistic insights into aging patterns in Drosophila melanogaster. Specifically, we characterized metabolomic change over adult lifespan in populations of D. melanogaster where selection for early reproduction has led to an accelerated aging phenotype relative to their controls. Using these data we: i) evaluated evolutionary repeatability across the metabolome; ii) assessed the value of the metabolome as a predictor of “biological age” i..., Data sets include full LC-MS data for 80 pooled metabolomic samples of adult female Drosophila melanogaster collected from 10 replicate populations under selection for early reproduction (A-type) and their controls (C-type) at four timepoints spanning adulthood. Normalized metabolomic data is also provided for this same data set. 
Additionally, mortality data for both males and females are presented for these same populations. , , # Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster

[https://doi.org/10.5061/dryad.1ns1rn92x](https://doi.org/10.5061/dryad.1ns1rn92x)

The Datasets consist of three files containing data from *Drosophila melanogaster* populations under selection for early reproduction (A-type), their controls (C-type), and their sub-populations AO (A-type derived from O-type), ACO (A-type derived from C-type derived from O-type), CO (C-type derived from O-type), and nCO (new C-type derived from O-type).

1. The full LC-MS metabolomics data set for 80 pooled samples from adult females at four age classes (Metabolomics_Raw_Data.xlsx)
2. The normalized, mean-centered version of the same metabolomics data (A-C_Normalized_Metabolomics_Time_Series_Data.csv)
3. Mortality data for the same populations (Winter_2023_Mortality.csv)

## Description of the data and file structure

The full LC-MS metabolomics data (Metabolomics_Raw_Data.xlsx) i...,