Roles of Iron in Chemoresistance of Multiple Myeloma Depends on the Interaction with Bone Marrow Stromal Cells [treatment]

To investigate the role of iron(FeAc) on bortezomib-induced drug resistance of multiple myeloma cells, we administrated MM.1S with iron and bortezomib We then performed gene expression profiling analysis using data obtained from RNA-seq of four different groups,which treated with vehicle, iron(FeAc), bortezomib and iron(FeAc) plus bortezomib respectively.