Directing Group in Decarboxylative Cross-Coupling: Copper-Catalyzed Site-Selective C–N Bond Formation from Nonactivated Aliphatic Carboxylic Acids

Copper-catalyzed
directed decarboxylative amination of nonactivated
aliphatic carboxylic acids is described. This intramolecular C–N
bond formation reaction provides efficient access to the synthesis
of pyrrolidine and piperidine derivatives as well as the modification
of complex natural products. Moreover, this reaction presents excellent
site-selectivity in the C–N bond formation step through the
use of directing group. Our work can be considered as a big step toward
controllable radical decarboxylative carbon–heteroatom cross-coupling.