RareBliss: Rare Bipolar Loci Identification Through Sequencing Study

Bipolar disorder is a complex psychiatric disease for which few causative genes have been discovered. Targeted sequencing of bipolar cases and unaffected controls was performed to elucidate the contribution of rare variants to bipolar disorder. This study included the standard exome targets as well as genes involved in synaptic function and genes previously implicated in bipolar disorder.]]> All case subjects were evaluated with the Diagnostic Interview for Genetic Studies or the Schedule for Affective Disorders and Schizophrenia. In addition, medical records were examined prior to diagnosis. All case subjects provided written informed consent. All control subjects were obtained from the NIMH Genetics Initiative repository. The control subjects completed the Composite International Diagnostic Interview-Short Form along with additional questions about any history of psychiatric disease. Control subjects also provided informed consent.]]>