TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.

TRAF6 通过TAK1介导的IKK复合物的经典磷酸化激活NFkB。TRAF6与TAK1亦调控MAPK级联反应，进而激活AP-1。