WGS of RPE-1 cells with PICH deficiency
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https://www.ncbi.nlm.nih.gov/sra/SRP517847
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资源简介：
PICH depletion in non-transformed diploid cells RPE-1 induces DNA damage, micronuclei formation, p53 activation, G1-phase arrest, and cell death. Whole-genome sequencing reveals that segregation defects induced by PICH depletion cause chromosomal rearrangements, including translocations and inversions, emphasizing its significance in preserving genomic integrity.
创建时间：
2024-10-14
