MicroRNA differential expression in skin and oral mucosal epithelium

While skin and oral mucosa share many morphological similarities, oral mucosal wounds heal more rapidly than skin wounds. Epithelial cells from oral mucosa exhibit increased migratory and proliferative capacities when compared to cells from skin, suggesting that the improved repair of mucosa may involve intrinsic differences in epithelial cells. This is an exploratory experiment to define the differential microRNA expression of baseline unwounded skin and oral mucosa epithelium. Microarray-based microRNA profiling were performed on pooled total RNA samples isolated from paired skin and oral mucosa specimens of mouse (n=3) were profiled .