HUMAN HGPRT in complex with [(2-[(guanin-9-yl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)diphosphonic acid

HUMAN HGPRT in complex with [(2-[(guanin-9-yl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)diphosphonic acid Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, {[(2R)-2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl}phosphonic acid Authors: Guddat, L.W, Keough, D.T. Deposit date: 2017-06-22 Release date: 2017-08-30 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.346 Å) Cite: Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase. J. Med. Chem., 60, 2017

人类次黄嘌呤-鸟嘌呤磷酸核糖转移酶（HGPRT）与[(2-[(鸟嘌呤-9-基)甲基]丙烷-1,3-二基)双(氧)]双(亚甲基)二膦酸形成的复合物。描述内容：次黄嘌呤-鸟嘌呤磷酸核糖转移酶、镁离子（MAGNESIUM ION）、{[(2R)-2-[(2-氨基-6-氧代-1,6-二氢-9H-嘌呤-9-基)甲基]-3-(2-膦酰乙氧基)丙氧基]甲基}膦酸。作者：Guddat, L.W、Keough, D.T.。存入日期：2017-06-22；发布日期：2017-08-30；最后修改日期：2024-03-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.346埃（Å）。引用文献：《不对称无环核苷双膦酸酯的合成与评价——作为恶性疟原虫与人类次黄嘌呤-鸟嘌呤-(黄嘌呤)磷酸核糖转移酶抑制剂》，《药物化学杂志》（J. Med. Chem.），第60卷，2017年。