The effect of respiratory phenotypes and lifestyle on the levels of DNA methylation in the NPSR1 promoter region covering CpG site 1 to 12 in adults from the BIOAIR study (n = 171) using adjusted linear regression models.

COPD – Chronic Obstructive Pulmonary Disease, BMI – Body Mass Index, FEV1 – Forced Expiratory Volume in 1 second, FVC – Forced Vital Capacity. Mild asthma patients were used as reference in the comparison to severe asthma and COPD. P: p-value for linear regression model adjusted for age, gender and country of origin. Age and gender were also adjusted for asthma and other obstructive airway disease (mild asthma, severe asthma or COPD).*Data analyzed in homozygous carriers of the C allele only (nmild asthma/severe asthma/COPD = 47/56/44),**Data analyzed in homozygous carriers of the C allele only (nmild asthma/severe asthma/COPD = 38/45/33),†Data analyzed in homozygous carriers of the C allele only (nmild asthma/severe asthma/COPD = 16/27/19),††Data analyzed in homozygous carriers of the G allele only (nmild asthma/severe asthma/COPD = 10/20/10).