Physiologic conditions at the beginning and end of ventilation.

At the end of the study period, we obtained data of arterial blood gases and mean arterial pressure from the nonventilated control mice and mice subjected to VT at 30 mL/kg for 4 h (n = 10 per group). We maintained the normovolemic statuses of mice by monitoring the mean artery pressure. Data are presented as means ± SDs. *indicates that P<0.05 when compared to the nonventilated control mice with room air and †indicates that P<0.05 when compared to all other groups. iPSC = induced pluripotent stem cell; MAP = mean arterial pressure; PIP = peak inspiratory pressure; Src+/− = Src-deficient mice; VT = tidal volume. The physiological data on the nonventilated control groups were similar during the experiment and were used as ventilation start data.
Physiologic conditions at the beginning and end of ventilation.