A Facile and Efficient Asymmetric Synthesis of Florfenicol
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下载链接：
http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1289858
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资源简介：
A facile and efficient enantioselective synthesis of florfenicol
starting from commercially available 4-methylthiobenzaldehyde is
described. Key features of the synthesis include a one-step oxidation
of allyl and thioether groups in allylic alcohol to form (2S,3S)-epoxide
under Sharpless epoxidation conditions and a highly efficient conversion
of (1R,2R)-azide
into amino alcohol via debenzylation and reduction of an azido moiety
in one-pot operation.
提供机构：
Georg Thieme Verlag, Stuttgart, New York
创建时间：
2011-12-12
