Synthesis of Novel Hexahydroindoles from the Dearomatization of Indoline
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https://figshare.com/articles/dataset/Synthesis_of_Novel_Hexahydroindoles_from_the_Dearomatization_of_Indoline/2066424
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资源简介：
The
transiently stable indoline complex TpW(NO)(PMe3)(η2-N-ethyl-6,7-indoline) is shown
to be a synthon for a broad range of novel hexahydroindoles. The tungsten
dearomatizes the indoline, allowing for its sequential protonation,
electrophilic addition (e.g., protonation, fluorination, hydroxylation,
acylation), nucleophilic addition (e.g., amination, arylation, etheration,
alkylation), and reduction, all with well-defined and predictable
stereochemistry. The tungsten stereocenter directly governs the stereoselective
formation of four adjacent asymmetric carbons originating from the
aromatic ring of the indoline.
创建时间：
2016-02-02
