A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis
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A mutation in porcine pre-miR-15b alters the biogenesis of MiR-15b\16-1 cluster and strand selection of MiR-15b
MicroRNAs (miRNAs) are small non-coding RNAs that are involved in translational regulation of the messenger RNA molecules. Sequence variations in the genes encoding miRNAs could influence their biogen
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Somatic mutations identified in 3′-untranslated regions of candidate mRNAs.
1Nucleotide changes are described relative to the following sequences: AKT2 NM_001626.3; CTNNB1 NM_001904.3; EGFR NM_005228.3; ERBB2 NM_004448.2. 2Indicates that the somatic mutation occurs within the
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Additional file 6 of Evaluation of the potential role of long non-coding RNA LINC00961 in luminal breast cancer: a case–control and systems biology study
Additional file 6: File S3. The list of LINC00961 mutations across breast cancer datasets, obtained using the ICGC portal.
Figshare2020-10-02 更新20
A non-coding mutation implicates HCFC1 in non-syndromic intellectual disability. Homo sapiens
Human disease mutation discovery has so far been biased towards protein coding regions. Having excluded all annotated coding regions, we performed targeted massively parallel re-sequencing of the non-
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Robust growth on uridine at 37°C requires the lon promoter mutation.
aAll grew on uridine at 37°C. bThe sroGm1 mutation is C3182707T and the sroGm2 mutation is A3182644G. Both are in stems of the riboswitch structure and would prevent base pairing. cThe orientation of
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