RNA-sequencing for kidneys derived from adult Pkd1 knock-out (KO) mice treated with salsalate for two weeks

To investigate the early and direct effects of short salsalate administration on gene expression & pathways in polycystic kidney disease. Pkd1 was knocked-out at PN18, and mice remained untreated until PN81, after which half of the experimental group received a two-week salsalate treatment. Mice were sacrificed at PN95 Overall design: Comparative gene expression profiling analysis of RNA-seq data for iKspCre-Pkd1del mice, either wildtype (not induced), untreated PKD mice, or two-week salsalate-treated PKD mice