Total Synthesis of (−)-Nakadomarin A

A concise diastereoselective total synthesis of (−)-nakadomarin A has been completed in 21 steps from d-pyroglutamic acid. Key steps include an enecarbamate Michael addition/furan-N-acyliminium ion cascade cyclization to provide the tetracyclic core and ring-closing alkyne and alkene metatheses to construct the fifteen- and eight-membered azacycles, respectively.

已完成从d-吡咯丙氨酸出发的（-）-nakadomarin A的简洁立体选择性全合成，共21步。关键步骤包括烯羰酸酯Michael加成/呋喃-N-酰亚胺离子级联环化以提供四环核心，以及环闭烷基和烯基互变异构以分别构建十五元和八元杂环。