P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.
收藏PubMed Central1996-07-23 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC38811/
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资源简介：
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. This factor, referred to as P-OTX (pituitary OTX-related factor), is expressed in primordial Rathke's pouch, oral epithelium, first bronchial arch, duodenum, and hindlimb. In the developing anterior pituitary, it is expressed in all regions from which cells with distinct phenotypes will emerge in the mature gland. P-OTX is able to independently activate and to synergize with Pit-1 on pituitary-specific target gene promoters. Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-07-23
